• DiscoveryProbe™ Metabolism-related Compound Library: Technic

  2026-08-04

  The DiscoveryProbe™ Metabolism-related Compound Library addresses workflow bottlenecks in in vitro and ex vivo metabolism research by providing 493 quality-controlled, cell-permeable small molecules targeting key metabolic processes. It is best suited for enzyme inhibition/activation assays, pathway studies, and high-throughput screening, but is not intended for diagnostic, medical, or in vivo use.

• SARS-CoV-2 Nucleocapsid Protein Suppresses GADD34-IRF3 Immun

  2026-08-04

  This study uncovers a mechanism by which the SARS-CoV-2 nucleocapsid protein disrupts the GADD34-mediated innate immune pathway. By sequestering GADD34 mRNA into atypical stress granule foci, viral N protein impairs IRF3 nuclear translocation, weakening interferon responses and facilitating viral replication.

• SU 5402 in Translational Research: Beyond Oncology Frontiers

  2026-08-03

  This thought-leadership article explores the strategic and mechanistic power of SU 5402, a benchmark receptor tyrosine kinase inhibitor, for translational researchers. We bridge its well-established role in cancer biology with emerging applications in neurovirology, leveraging primary literature and advanced protocols to guide translational workflows. Drawing on recent breakthroughs in human sensory neuron models for latent viral infection, we illuminate how SU 5402 enables high-fidelity interrogation of cell signaling, apoptosis, and cell cycle dynamics, while offering actionable guidance for maximizing experimental rigor in both oncology and neuronal research.

• ZDHHC4-Mediated Palmitoylation Regulates TRPV1 and Pain Reli

  2026-08-03

  This article reviews recent evidence that S-palmitoylation of TRPV1 by ZDHHC4 promotes lysosomal degradation of the channel, thereby facilitating inflammatory pain relief. The findings reveal a previously underexplored mechanism of pain resolution and highlight the dynamic regulation of TRPV1 by lipid modification, offering new avenues for dissecting pain pathways.

• PRMT6-Mediated Arginine Methylation Enhances Antiviral Immun

  2026-08-02

  Zhu et al. (2024) identify protein arginine methyltransferase 6 (PRMT6) as a critical mediator of plant antiviral immunity, specifically against tomato bush stunt virus (TBSV). Their work reveals that PRMT6 targets conserved arginines in the viral P19 protein, disrupting its silencing suppressor function and linking natural PRMT6 alleles to resistance among tomato cultivars.

• EdU Imaging Kits: Precision Cell Proliferation Assay Workflo

  2026-08-01

  EdU Imaging Kits (HF488) empower researchers to quantify DNA synthesis and cell proliferation with unmatched sensitivity and workflow efficiency. This guide explores their applied use-cases, detailed protocols, and troubleshooting strategies, revealing how these kits—by leveraging 5-ethynyl-2'-deoxyuridine and click chemistry—outperform traditional assays in oncology research and drug response studies.

• Arachidonic Acid: Molecular Mechanisms and Translational Imm

  2026-07-31

  Explore the advanced roles of arachidonic acid, a key polyunsaturated omega-6 fatty acid, in immune modulation and cellular signaling. This article uniquely integrates molecular mechanism insights with translational assay guidance for immunology research.

• BKT140 (BL-8040): Enhancing CXCR4 Inhibition in Cancer Resea

  2026-07-31

  BKT140 (BL-8040) empowers oncology research with precise CXCR4 antagonism, supporting workflows from tumor microenvironment studies to robust stem cell mobilization assays. Its high solubility and clinical-grade purity eliminate formulation guesswork and drive reproducible, high-impact results.

• ABT-737 (A8193): Reliable BCL-2 Inhibition for Cancer Assays

  2026-07-30

  This article explores how ABT-737 (SKU A8193), a robust BCL-2 protein inhibitor, addresses critical workflow challenges in apoptosis assays and antitumor studies. Scenario-driven Q&As detail data-backed best practices, ensuring reproducibility and sensitivity for cell viability, proliferation, and cytotoxicity assays.

• Amyloid Beta-peptide (25-35): Applied Workflows in AD Models

  2026-07-30

  Amyloid Beta-peptide (25-35) (Aβ25-35) is the benchmark neurotoxic fragment for modeling Alzheimer's disease mechanisms, enabling precise dissection of microglial activation and neurodegeneration. This guide translates new mechanistic insights and workflow upgrades—grounded in the latest reference study—into actionable steps and troubleshooting strategies for reproducible, high-impact experiments.

• NFE2L1-DDI2 Axis Protects Against Ferroptosis via Proteasome

  2026-07-29

  This study uncovers how activation of the NFE2L1-ubiquitin-proteasome system by DDI2 buffers cells against ferroptosis. The findings provide mechanistic insight into the interplay between protein homeostasis and iron-dependent cell death, with implications for ferroptosis modulation in cancer biology.

• Efficient Synthesis of Deuterium-Labeled Degarelix Acetate

  2026-07-29

  This study introduces a 13-step, high-yield method for synthesizing deuterium-labeled degarelix acetate, supporting robust clinical and pharmacokinetic research. The innovation advances internal standard preparation for drug metabolism studies, with broader implications for androgen-related disease research.

• Pseudo-UTP: Precision Engineering of RNA for Advanced Therap

  2026-07-28

  Explore how pseudo-modified uridine triphosphate (Pseudo-UTP) empowers next-generation mRNA synthesis with enhanced stability, translational efficiency, and reduced immunogenicity. This article uniquely dissects molecular mechanisms, protocol considerations, and practical insights for therapeutic RNA innovation.

• (1S,3R)-RSL3: Precision Glutathione Peroxidase 4 Inhibitor

  2026-07-28

  (1S,3R)-RSL3 is a potent and selective glutathione peroxidase 4 inhibitor that induces ferroptosis through GPX4 blockade and ROS accumulation. This agent enables quantitative studies of oxidative stress and synthetic lethality in RAS-driven cancer models. RSL3 is integral for dissecting nonapoptotic cell death mechanisms in cancer biology.

• Lycopene Mitigates DON-Induced Intestinal Barrier Dysfunctio

  2026-07-27

  This study demonstrates that lycopene can counteract deoxynivalenol-induced intestinal barrier disruption and inflammasome activation in IPEC-J2 cells by targeting ERK signaling. The findings highlight a mechanistic link between dietary antioxidants and protection against mycotoxin-induced gut inflammation, with implications for translational immunofluorescence research.

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